◀ Back to STAT1
STAT1 — TYK2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
STAT1
→
TYK2
(increases, TYK2 Activity)
Novak et al., Blood 1995*
Evidence: The activation of the STAT proteins in BMM is accompanied by tyrosine phosphorylation of Tyk2. In fibroblasts, the activation of the STAT proteins is accompanied by tyrosine phosphorylation of Tyk2 and JAK1.
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BioCarta ifn alpha signaling pathway:
IFN-alpha/IFNAR1/IFNAR2/JAK1/TYK2 complex (IFNAR2-JAK1-IFNAR1-IFNA1-TYK2)
→
STAT1
(modification, activates)
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BioCarta il22 soluble receptor signaling pathway:
STATs (STAT3/STAT5A/STAT1/STAT5A/STAT5B/STAT5B)
→
IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1)
(modification, collaborate)
-
BioCarta il22 soluble receptor signaling pathway:
IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1)
→
STATS/STATS complex (STAT3_STAT5A_STAT1_STAT5A_STAT5B_STAT5B)
(modification, activates)
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KEGG Osteoclast differentiation:
JAK1/TYK2
→
STAT1/STAT2
(protein-protein, activation)
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KEGG Jak-STAT signaling pathway:
JAK1/JAK2/JAK3/TYK2
→
STAT1/STAT2/STAT3/STAT4/STAT5A/STAT5B/STAT6
(protein-protein, phosphorylation)
-
KEGG Hepatitis C:
JAK1/TYK2
→
STAT1/STAT2
(protein-protein, activation)
-
KEGG Measles:
JAK1/TYK2
→
STAT1/STAT2
(protein-protein, activation)
-
KEGG Influenza A:
JAK1/TYK2
→
STAT1/STAT2
(protein-protein, activation)
-
NCI Pathway Database IL23-mediated signaling events:
STAT1 (STAT1)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Parham et al., J Immunol 2002
Evidence: physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
STAT1 (STAT1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT1 (dimer) complex (STAT1)
(modification, activates)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL27-mediated signaling events:
STAT1 (STAT1)
→
IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3)
(modification, collaborate)
Lucas et al., Proc Natl Acad Sci U S A 2003
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT1 (STAT1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
Reactome Reaction:
STAT1
→
TYK2
(indirect_complex)
-
Reactome Reaction:
TYK2
→
STAT1
(reaction)
Mowen et al., Mol Cell Biol 2000, Wesoly et al., Acta biochimica Polonica 2007, Müller et al., Nature 1993, Li et al., J Biol Chem 1996
-
Reactome Reaction:
TYK2
→
STAT1
(indirect_complex)
-
Reactome Reaction:
STAT1
→
TYK2
(reaction)
Mowen et al., Mol Cell Biol 2000, Wesoly et al., Acta biochimica Polonica 2007, Shuai et al., Cell 1994, Müller et al., Nature 1993, Li et al., J Biol Chem 1996
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
TYK2
—
STAT1
(direct interaction, enzymatic study)
Usacheva et al., J Immunol 2003
-
IRef Hprd Interaction:
TYK2
—
STAT1
(in vivo)
Hart et al., Oncogene 2000, Hart et al., Mol Biol Cell 2001, Uddin et al., J Biol Chem 2002, Dimberg et al., Blood 2003*, Deb et al., J Immunol 2003, DeVries et al., J Biol Chem 2004, Wen et al., Cell 1995*, Quelle et al., J Biol Chem 1995, Shuai et al., Science 1993
-
IRef Hprd Interaction:
TYK2
—
STAT1
(in vitro)
Hart et al., Oncogene 2000, Hart et al., Mol Biol Cell 2001, Uddin et al., J Biol Chem 2002, Dimberg et al., Blood 2003*, Deb et al., J Immunol 2003, DeVries et al., J Biol Chem 2004, Wen et al., Cell 1995*, Quelle et al., J Biol Chem 1995, Shuai et al., Science 1993
Text-mined interactions from Literome
Aoki et al., Exp Hematol 2003
:
Phosphorylation of
Stat1 by limitin is partially
dependent on
Tyk2
Kasper et al., J Interferon Cytokine Res 2007
:
However, GM-CSF induced downregulation of
Tyk2 and Jak1 tyrosine phosphorylation as well as Tyk2 protein levels likely
contributed to the reduced
Stat1 tyrosine phosphorylation
Prchal-Murphy et al., PloS one 2012
(Genetic Predisposition to Disease...) :
We show that kinase-active
TYK2 is
required for full fledged type I interferon- ( IFN ) induced activation of the transcription factors
STAT1-4 and for the in vivo antiviral defence against viruses primarily controlled through type I IFN actions
Herzig et al., Shock 2012
(Bacteremia...) :
TYK2 is
essential for type I, but not type II, IFN induced
STAT1 activation
Bhattacharjee et al., Free Radic Biol Med 2013
:
We further show that Jak2 is upstream of Stat3 activation and
Tyk2 controls
Stat1 and Stat6 activation in response to IL-13 stimulation
Haque et al., J Biol Chem 1995
:
Interestingly, ligand independent
Stat1 alpha activation by peroxo-derivatives of these transition metals does not
require Jak1, Jak2, or
Tyk2 kinase activity, suggesting that other kinases can phosphorylate Stat1 alpha on tyrosine 701
Quelle et al., J Biol Chem 1995
:
Co-expression of Stat1 with
Tyk2 , Jak1, or Jak2
resulted in the specific tyrosine phosphorylation of
Stat1 at Tyr701, the residue phosphorylated in mammalian cells stimulated with interferon gamma
Eilers et al., Cell Growth Differ 1996
:
TYK2 activity
led to an IFN-alpha independent appearance of tyrosine phosphorylated
STAT1 but not STAT2 or JAK1 proteins
Gatsios et al., J Biol Chem 1998
:
In this study, we demonstrate that in different cell lines a particular stress, namely hyperosmolarity, results in tyrosine phosphorylation of the Janus kinases Jak1, Jak2, and
Tyk2 and in the
activation of
STAT1 and/or STAT3