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LIF — TYK2

Text-mined interactions from Literome

Halfter et al., Mol Cell Biol Res Commun 1999 (Glioma) : While OSM induces a number of strong tyrosine phosphorylations, including Janus tyrosine kinases ( Jak ) and the signal transducer and activator of transcription ( Stat ) proteins, LIF induces only minor tyrosine phosphorylation of Tyk2 and Stat3
Rajasingh et al., Exp Cell Res 2006 : Immunoprecipitation and Western blot analyses showed that LIF induces tyrosine phosphorylation of JAK1, TYK2 and STAT3 in 30 min and treatment with 15d-PGJ2 or ATRA results in a dose dependent decrease in LIF induced phosphorylation of JAK1 and STAT3 in D3-ES cells
Mo et al., Cell Signal 2010 : While 15d-PGJ2 and ciglitazone induced growth-arrest in ES cells by blocking LIF signaling, PPARgamma antagonists and dominant negative PPARgamma1 mutant reversed proliferation by restoring LIF induced Tyk2-Stat3 signaling