◀ Back to WNT2

MSX1 — WNT2

Text-mined interactions from Literome

Monsoro-Burq et al., Dev Cell 2005 : Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction ... Msx1 induces Pax3 and ZicR1 cell autonomously, in turn, Pax3 combined with ZicR1 activates Slug in a WNT dependent manner
Revet et al., Cancer Lett 2010 (Neuroblastoma) : MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3 ... We show that MSX1 induces the expression of four different Wnt pathway inhibitor genes : Dickkopf 1-3 (DKK1-3) and secreted frizzled related protein 1 ( SFRP1 ), and provide evidence that high expression of two of these genes correlates with good prognosis ... These results suggest involvement of MSX1 in Wnt signalling and demonstrate activity of the more upstream Wnt pathway in neuroblastic cells