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BRCA1 — BRCA3
Text-mined interactions from Literome
Choudhury et al., J Biol Chem 2005
:
In vivo,
BRCA1 exists as a heterodimer with the BARD1 protein, and many of its biological functions are
mediated by the
BRCA1-BARD1 complex
Sankaran et al., Cancer Biol Ther 2007
(Aneuploidy) :
By controlling gamma-TuRC localization,
BRCA1 appropriately inhibits centrosome function, and loss of
BRCA1 would
result in centrosome hyperactivity, supernumerary centrosomes and, possibly, aneuploidy
Romagnolo et al., Mol Carcinog 1998
(Breast Neoplasms...) :
The antiestrogen ICI-182780 inhibited estrogen induced cell proliferation,
BRCA1 mRNA
induction , and
BRCA1 protein expression in ER-positive cells