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BRCA1 — SMC2
Text-mined interactions from Literome
Kitagawa et al., Genes Dev 2004
(Chromosome Aberrations) :
Here, we show that NBS1 and
BRCA1 are required for the recruitment of previously activated ATM to the sites of DNA breaks after ionizing irradiation, and that this recruitment is
required for the phosphorylation of
SMC1 by ATM
Antoccia et al., Radiat Res 2008
(Chromosome Aberrations...) :
It is noted that
BRCA1 is
required for the interaction of NBS1 with
SMC1 , whereas the reverse is not the case, since BRCA1 is able to bind to NBS1 in the absence of an NBS1/SMC1 interaction as observed in MRE11- or RAD50-deficient cells ... Our results reveal that ATM plays a fundamental role in promoting the radiation induced interaction of NBS1 with
SMC1 in the
presence of
BRCA1 , leading to the maintenance of chromosomal integrity