Chiang et al., FEBS Lett 2007
(Breast Neoplasms) :
The use of pharmacological inhibitors revealed that the modulation of Akt, mTOR and JNK phosphorylation was required for diosgenin induced FAS suppression
Yue et al., BMB Rep 2010
:
The expressions of CCAAT/enhancer binding protein-alpha ( C/EBP-alpha ) and fatty acid synthase (FAS) protein were gradually enhanced during the 10-day duration while mTOR phosphorylation and sterol-regulatory-element binding protein ( SREBP)-1c protein were induced on day 4
Jensen-Urstad et al., J Lipid Res 2013
:
Rapamycin induced inhibition of mammalian/mechanistic target of rapamycin complex 1 ( mTORC1 ), a mediator of the feeding/insulin signal to induce lipogenesis, reduced FAS phosphorylation, increased cytoplasmic FAS enzyme activity, and increased PPARa target gene expression