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IL33 — MTOR
Text-mined interactions from Literome
Ohtani et al., Blood 2008
(Leishmaniasis, Cutaneous) :
Mammalian target of rapamycin and glycogen synthase kinase 3 differentially
regulate lipopolysaccharide induced
interleukin-12 production in dendritic cells
Salmond et al., J Allergy Clin Immunol 2012
(Pneumonia) :
Our goal was to investigate a role for mammalian target of rapamycin
(mTOR) signaling in the activation of T ( H ) 2 and ILC responses and the
induction of airway inflammation by
IL-33 ... We biochemically determined the
effect of
IL-33 on
mTOR activation in T ( H ) 2 cells and ILCs and examined the effect of this signaling pathway in vivo using a murine model of IL-33 induced lung inflammation ... We found that
IL-33 induces
mTOR activation through p110d phosphoinositide 3-kinase and that blockade of the mTOR pathway inhibited IL-33 induced IL-5 and IL-13 production by T ( H ) 2 cells and ILCs