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CASP7 — MYLIP
Text-mined interactions from Literome
Levrand et al., Free Radic Biol Med 2006
(Myocardial Ischemia) :
In vivo,
MIR triggered myocardial oxidative stress ( malondialdehyde generation ), nitrotyrosine formation, neutrophil accumulation, and the cleavage of
caspase-3 and PARP, indicating ongoing myocardial apoptosis
Xu et al., J Cell Sci 2007
:
By contrast,
miR-133 repressed
caspase-9 expression at both the protein and mRNA levels ... Post-transcriptional
repression of HSP60 and HSP70 by miR-1 and of
caspase-9 by
miR-133 contributes significantly to their opposing actions
Corsten et al., Cancer Res 2007
(Brain Neoplasms...) :
With the use of locked nucleic acid ( LNA ) -antimiR-21 oligonucleotides, bimodal imaging vectors, and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor related apoptosis inducing ligand ( S-TRAIL ), we show that the combined suppression of
miR-21 and NPC-S-TRAIL
leads to a synergistic increase in
caspase activity and significantly decreased cell viability in human glioma cells in vitro
Ferracin et al., Molecular cancer 2010
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
Importantly, inhibition of miR-21 and
miR-222 by anti-miRNA oligonucleotides induced a significant
increase in
caspase activity in fludarabine treated p53-mutant MEG-01 cells, suggesting that miR-21 and miR-222 up-regulation may be involved in the establishment of fludarabine resistance
Zhou et al., Oncol Rep 2010
(Brain Neoplasms...) :
Moreover, reduction of
miR-21 activated
caspase 9 and 3, which may be mediated by modulating multiple potential target genes, such as TIMP3
Druz et al., Biotechnol Bioeng 2011
:
The inhibition of the
mmu-miR-466h increased the expression levels of those genes and
resulted in increased cell viability and decreased
Caspase-3/7 activation
Dar et al., J Biol Chem 2011
(Melanoma...) :
miR-205 overexpression
resulted in induction of apoptosis, as evidenced by increased cleaved
caspase-3 , poly- ( ADP-ribose ) polymerase, and cytochrome c release
Feng et al., Nucleic Acids Res 2011
(Lung Neoplasms) :
Both
caspase-7 and the PARP protein were
activated by the overexpression of
miR-192 , thus suggesting that miR-192 induces cell apoptosis through the caspase pathway
Fang et al., Apoptosis 2012
(Myocardial Ischemia) :
This study first showed that
miR-378 inhibited
caspase-3 expression and attenuated ischemic injury in cardiomyocytes
Fitzgerald et al., Fertil Steril 2012
(Leiomyoma...) :
Loss of
miR-21 also
increased cleavage of
caspase-3 ( apoptosis marker ) and increased phosphorylation of elongation factor-2 ( marker of reduced translation ) in both cell lines
Bao et al., Apoptosis 2013
(Myocardial Infarction...) :
We found that cleaved
caspase3 expression was
up-regulated by
miR-384-5p and down-regulated by miR-384-5p inhibitor suggesting that apoptosis pathway was regulated by miR-384-5p
Rong et al., BMC cancer 2013
(Carcinoma, Hepatocellular...) :
The
effects of
miR-221 on cell growth, cell cycle,
caspase activity and apoptosis were also investigated by spectrophotometry, fluorimetry, fluorescence microscopy and flow cytometry, respectively
Druz et al., Metab Eng 2013
:
Mmu-miR-466h-5p was previously shown to have a pro-apoptotic role in CHO cells by reducing the expression of several anti-apoptotic genes and its transient inhibition
delayed both the activation of
Caspase-3/7 and the loss of cell viability
Li et al., Biochem J 2013
(Airway Remodeling...) :
Expression of exogenous
miR-138 suppressed PASMC apoptosis,
prevented caspase activation and disrupted Bcl-2 signalling
Nakano et al., Int J Oncol 2013
:
Overexpression of
miR-193a and miR-193b
induced an activation of
caspase 3/7, and resulted in apoptotic cell death in A2780 cells
Wang et al., Cell death & disease 2013
:
miR-874 regulates myocardial necrosis by targeting
caspase-8