Gene interactions and pathways from curated databases and text-mining

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MAPK1 — MYLIP

Text-mined interactions from Literome

Cheng et al., Neuron 2007 (MAP Kinase Signaling System) : miR-132 is induced by photic entrainment cues via a MAPK/CREB dependent mechanism, modulates clock-gene expression, and attenuates the entraining effects of light
Kim et al., J Biol Chem 2008 (Neoplasm Invasiveness) : MicroRNA miR-199a* regulates the MET proto-oncogene and the downstream extracellular signal regulated kinase 2 ( ERK2 ) ... Interestingly, extracellular signal regulated kinase 2 ( ERK2 ) was also down-regulated by miR-199a*
Akhtar et al., Arthritis Rheum 2010 (Osteoarthritis) : NF-kappaB and MAPK activation down-regulated the expression of miR-27b
Cannell et al., Proc Natl Acad Sci U S A 2010 (MAP Kinase Signaling System) : p38 MAPK/MK2 mediated induction of miR-34c following DNA damage prevents Myc dependent DNA replication
Liu et al., PloS one 2011 (Neovascularization, Pathologic) : AKT and extracellular regulated kinases (ERK) 1/2 are activated by miR-21
Tan et al., FEBS Lett 2011 (Carcinoma, Hepatocellular...) : Forced expression of miR-198 decreased c-MET expression at both mRNA and protein levels and consequently diminished HGF induced phosphorylation of p44/42 MAPK in HCC cells
Zhang et al., FEBS Lett 2012 (Diabetic Nephropathies...) : We found that miR-451 negatively regulated the expression of Ywhaz through Ywhaz 3'UTR and that Ywhaz was required for the miR-451 mediated downregulation of p38 MAPK signalling ... These findings suggest that the growth-inhibitory effect of miR-451 may be explained in part by miR-451 induced suppression of Ywhaz and p38 MAPK signalling, providing evidence for the potential role of miR-451 in early DN
Liu et al., J Biol Chem 2011 : The up-regulation of rno-miR-31 in proliferative VSMCs was inhibited by the inhibitor of mitogen activated protein kinase/extracellular regulated kinase ( MAPK/ERK )
Ciuffreda et al., J Mol Med (Berl) 2012 (Disease Models, Animal...) : This appears to be a general regulatory mechanism and is mediated by multiple mechanisms, such as MAPK dependent c-Jun and miR-25 regulation
Sharma et al., EMBO Mol Med 2012 (Cardiomegaly...) : Repression of miR-142 by p300 and MAPK is required for survival signalling via gp130 during adaptive hypertrophy
Jude et al., Am J Physiol Lung Cell Mol Physiol 2012 (Asthma...) : TNF-a induced activation of p38 MAPK and NF-?B was attenuated by miR-140-3p mimic
Liang et al., Gastroenterology 2013 (Colorectal Neoplasms...) : Ectopic expression of miR-137 in CRC cells inhibited phosphorylation of mitogen activated protein kinase ( MAPK ) and Akt, which reduced levels of matrix metalloproteinase 2, matrix metalloproteinase 9, and vascular endothelial growth factor ; it also reduced invasiveness of CRC cells, inhibiting signaling via phosphatidylinositol-4,5-bisphosphate 3-kinase, Akt, and MAPK
Yang et al., Hepatology 2013 (Carcinoma, Hepatocellular...) : Multipathway reporter arrays suggested that miR-140-5p inhibited transforming growth factor ß ( TGF-ß ) and mitogen activated protein kinase / extracellular signal regulated kinase ( MAPK/ERK ) signaling
Chen et al., Biochem Pharmacol 2013 (Leukemia) : HQ-induced p38 MAPK and JNK activation were responsible for suppression of miR-122 promoter luciferase activity and miR-122 expression ... Activation of p38 MAPK and JNK elicited phosphorylation of c-Jun, ATF-2 and c-Fos, and knock-down of c-Jun, ATF-2 and c-Fos restored miR-122 expression in HQ-treated cells