Gene interactions and pathways from curated databases and text-mining

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NOTCH4 — RBX1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: NOTCH4 → Complex of CUL1-FBXW7-RBX1-SKP1 (decreases)

    Evidence: The involvement of Fbw7 in the control of the Notch pathway is confirmed by the finding that Notch4 accumulates in Fbw7-deficient embryos, which die in utero at embryonic day 10.5 and manifest abnormal vascular development