UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to PARP2

PARP2 — XRCC1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: XRCC1 — PARP2 (physical association, affinity chromatography technology) Schreiber et al., J Biol Chem 2002 *
IRef Hprd Interaction: PARP2 — XRCC1 (in vivo) Schreiber et al., J Biol Chem 2002 *
IRef Hprd Interaction: PARP2 — XRCC1 (in vitro) Schreiber et al., J Biol Chem 2002 *

Text-mined interactions from Literome

Schreiber et al., J Biol Chem 2002 : XRCC1 negatively regulates PARP-2 activity, as it does for PARP-1, while being a polymer acceptor for both PARP-1 and PARP-2
Ström et al., Nucleic Acids Res 2011 : Interestingly, we uncover a synthetic lethality between XRCC1 deficiency and PARP inhibition
Campalans et al., Nucleic Acids Res 2013 : We show first that XRCC1 recruitment to BER is independent of PARP