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HSF1 — PRKAR1A
Text-mined interactions from Literome
Ferguson et al., Genetics 2005
:
Previous studies had proposed that the stress response transcription factors Msn2p/4p, but not
Hsf1p , are
repressed by
PKA
Melling et al., J Mol Cell Cardiol 2006
(MAP Kinase Signaling System) :
Recently, we reported that administration of a protein kinase A (PKA) inhibitor suppressed exercise induced hsp70 gene expression, suggesting a
role for
PKA in the regulation of
HSF1 activation in vivo ... While the mechanism by which
PKA regulates
HSF1 is unclear, studies in vitro have reported that HSF1 is phosphorylated on two serine residues by mitogen activated protein kinases ( MAPKs ) ; ERK1/2 ( ser307 ) and JNK/SAPK ( ser363 ) ... Given that ERK1/2 has been shown to be a negative regulator of HSF1 in vitro, these results suggest a role for ERK1/2 in the
PKA mediated regulation of
HSF1 activation following exercise
Murshid et al., PloS one 2010
:
These findings of
PKA regulation of
HSF1 through S320 phosphorylation add to our knowledge of the signaling networks converging on this factor and may contribute to elucidating its complex roles in the stress response and understanding HSF1 dysregulation in disease