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NOS1 — PRKAR1A
Text-mined interactions from Literome
Yu et al., Brain Res Mol Brain Res 2002
(Synaptic Transmission) :
Our data indicate that the protein inhibitor of nNOS (PIN) binds to protein kinase A inhibitors ( PKIs ), which suggests that PKIs, together with PIN, might
mediate the phosphorylation of
nNOS by
PKA
Jaureguiberry et al., Peptides 2004
:
The stimulatory effect of ETs on
NOS activity was inhibited in the
presence of PLC, PKC,
PKA and CaMK-II inhibitors ( U-73122, GF-109203X, H-89 and KN-62, respectively ), and the IP3 receptor selective antagonist, 2-APB
Rodriguez et al., Anim Reprod Sci 2005
:
These results indicate that NO* may be generated by a sperm
NOS during heparin induced capacitation and that exogenous NO* acts as a capacitation inducer and
involves the participation of
PKA , PKC and PTK as part of the intracellular mechanisms that lead to capacitation in cryopreserved bull spermatozoa
Queen et al., J Physiol 2006
:
beta ( 2 ) AR activation also increased
NOS activity and phosphorylation of NOS-3 on serine-1177, and these increases were
attenuated by inhibition of
protein kinase A (PKA) , phosphatidylinositol 3-kinase (PI3K) or Akt, and abolished by coinhibition of PKA and Akt
Ohnishi et al., J Neurochem 2008
:
These results demonstrate that PACAP stimulated
nNOS translocation
mediated by
PKA and PKC via PAC(1)-receptor ( a PACAP receptor ) and suggest cross-talk between PACAP and NMDA for nNOS activation by Src dependent phosphorylation of NMDA receptors
Yen et al., J Biomed Sci 2011
:
The possibility of
PKA dependent
nNOS activation was substantiated by immunohistochemical demonstration of co-localization of PKA and nNOS in putative NTS neurons
Song et al., Int J Mol Med 2012
:
The phosphorylation levels of
nNOS at Ser1412,
induced by activation of Akt/PKB or CaM-K II, but not by
PKA signaling, were reduced by pre-treatment with the NO donor diethylamine-NONOate ... Furthermore, the levels of phosphorylation of
nNOS at Ser1412,
induced by Akt/PKB or CaM-K II but not by
PKA signaling, were enhanced by inhibition of nNOS activity with 7-nitroindazole
Wang et al., Exp Neurol 2013
:
Involvement of
PKA dependent upregulation of
nNOS-CGRP in adrenomedullin initiated mechanistic pathway underlying CFA induced response in rats