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PRKAR1A — SCT
Text-mined interactions from Literome
Lesage et al., Hepatology 2002
:
Insulin induced activation of PKC alpha, which decreased
secretin stimulated cAMP and
PKA activity
Francis et al., Am J Physiol Cell Physiol 2007
(Bile Duct Diseases) :
In BDL rats, UK 14,304 inhibited
secretin stimulated 1 ) bile and bicarbonate secretion, 2 ) expansion of IBDU luminal spaces, and 3 ) cAMP levels,
PKA activity, Cl ( - ) efflux, and Cl ( - ) /HCO ( 3 ) ( - ) exchanger activity in cholangiocytes
Glaser et al., Hepatology 2010
(Cholestasis, Extrahepatic...) :
In vitro,
secretin increased proliferation,
PKA activity, and ERK1/2 phosphorylation of large cholangiocytes that was blocked by PKA and mitogen activated protein kinase kinase inhibitors
Mahata et al., Cell Tissue Res 2011
:
In agreement,
secretin increased
PKA activity and induced phosphorylation of CREB and binding to Th CRE, suggesting secretin signaling to transcription via a PKA-CREB pathway
Úriz et al., PloS one 2011
(Choledochal Cyst...) :
Experiments with inhibitors and Ca ( 2+ ) -chelator confirmed that the synergistic
effect of
secretin plus TUDCA involves microtubules, intracellular Ca ( 2+ ), PKCa, PI3K,
PKA and MEK pathways ... UDCA is conjugated in order to promote
secretin stimulated hydrocholeresis in rats through Ae2, microtubules, intracellular Ca ( 2+ ), PKCa, PI3K,
PKA , and MEK
Williams et al., J Neurosci 2012
:
Since
secretin receptors
activate PKA ( Wessels-Reiker et al., 1993 ), we tested the hypothesis that secretin regulates Kv1.2 trafficking in the cerebellum