UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to RAP1A

RAP1A — RAPGEF1

Pathways - manually collected, often from reviews:

KEGG Focal adhesion: RAPGEF1 → RAP1A/RAP1B (protein-protein, activation)
KEGG Neurotrophin signaling pathway: RAPGEF1 → RAP1A/RAP1B (protein-protein, activation)
KEGG Renal cell carcinoma: RAPGEF1 → RAP1A/RAP1B (protein-protein, activation)
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/CRK family/C3G/GAB2 complex (FRS3_FRS2-CRKL_CRK-PTPN11-RAPGEF1-GAB2) → RAP1/GDP complex (RAP1B_RAP1A) (modification, activates)
Kao et al., J Biol Chem 2001, Wu et al., J Neurosci 2001
Evidence: mutant phenotype, assay, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/CRK family/C3G/GAB2 complex (FRS3_FRS2-CRKL_CRK-PTPN11-RAPGEF1-GAB2) → RAP1/GTP complex (RAP1B_RAP1A) (modification, activates)
Kao et al., J Biol Chem 2001, Wu et al., J Neurosci 2001
Evidence: mutant phenotype, assay, other species
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): C3G (RAPGEF1) → RAP1/GDP complex (RAP1B_RAP1A) (modification, activates)
Sakkab et al., J Biol Chem 2000, Lyle et al., Cell Signal 2008 *
Evidence: mutant phenotype, assay
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): C3G (RAPGEF1) → RAP1/GTP complex (RAP1B_RAP1A) (modification, activates)
Sakkab et al., J Biol Chem 2000, Lyle et al., Cell Signal 2008 *
Evidence: mutant phenotype, assay
NCI Pathway Database PDGFR-beta signaling pathway: C3G (RAPGEF1) → RAP1/GDP complex (RAP1B_RAP1A) (modification, activates)
Takahashi et al., Genes Cells 2008, Miyata et al., J Biol Chem 2009
Evidence: mutant phenotype, other species
NCI Pathway Database PDGFR-beta signaling pathway: C3G (RAPGEF1) → RAP1/GTP complex (RAP1B_RAP1A) (modification, activates)
Takahashi et al., Genes Cells 2008, Miyata et al., J Biol Chem 2009
Evidence: mutant phenotype, other species
NCI Pathway Database E-cadherin signaling in the nascent adherens junction: C3G (RAPGEF1) → RAP1/GDP complex (RAP1B_RAP1A) (modification, activates)
Hogan et al., Mol Cell Biol 2004 *, Fukuyama et al., Oncogene 2006
Evidence: mutant phenotype, other species
NCI Pathway Database E-cadherin signaling in the nascent adherens junction: C3G (RAPGEF1) → RAP1/GTP complex (RAP1B_RAP1A) (modification, activates)
Hogan et al., Mol Cell Biol 2004 *, Fukuyama et al., Oncogene 2006
Evidence: mutant phenotype, other species
NCI Pathway Database Signaling events mediated by focal adhesion kinase: C3G (RAPGEF1) → RAP1/GDP complex (RAP1B_RAP1A) (modification, activates)
Barberis et al., J Biol Chem 2000
Evidence: mutant phenotype
NCI Pathway Database Signaling events mediated by focal adhesion kinase: C3G (RAPGEF1) → RAP1/GTP complex (RAP1B_RAP1A) (modification, activates)
Barberis et al., J Biol Chem 2000
Evidence: mutant phenotype
NCI Pathway Database IFN-gamma pathway: CBL/CRKL/C3G complex (CRKL-RAPGEF1-CBL) → RAP1/GDP complex (RAP1B_RAP1A) (modification, activates)
Alsayed et al., J Immunol 2000
NCI Pathway Database IFN-gamma pathway: CBL/CRKL/C3G complex (CRKL-RAPGEF1-CBL) → RAP1/GTP complex (RAP1B_RAP1A) (modification, activates)
Alsayed et al., J Immunol 2000
NCI Pathway Database Nectin adhesion pathway: C3G (RAPGEF1) → RAP1/GDP complex (RAP1B_RAP1A) (modification, activates)
Fukuyama et al., J Biol Chem 2005 *, Ogita et al., Methods Enzymol 2006 *
Evidence: mutant phenotype, assay
NCI Pathway Database Nectin adhesion pathway: C3G (RAPGEF1) → RAP1/GTP complex (RAP1B_RAP1A) (modification, activates)
Fukuyama et al., J Biol Chem 2005 *, Ogita et al., Methods Enzymol 2006 *
Evidence: mutant phenotype, assay
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAP1/GDP complex (RAP1B_RAP1A) → KIDINS220/CRKL/C3G complex (CRKL-RAPGEF1) (modification, collaborate)
Arévalo et al., EMBO J 2004, Arévalo et al., J Biol Chem 2006
Evidence: mutant phenotype, physical interaction, other species
Reactome Reaction: RAP1A → RAPGEF1 (reaction)
WikiPathways Focal Adhesion: RAPGEF1 → RAP1A/RAP1B (activation)
WikiPathways Signaling of Hepatocyte Growth Factor Receptor: RAPGEF1 → RAP1A (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Bind_translation Interaction: RAP1A — RAPGEF1 (two hybrid) Dupuy et al., Oncogene 2005 *
IRef Dip Interaction: RAP1A — RAPGEF1 (direct interaction, gdp/gtp exchange assay) Mace et al., Nature structural & molecular biology 2011 *
STRING interaction: RAP1A — RAPGEF1 (interaction, mapped from reactome kegg_pathways)
STRING interaction: RAPGEF1 — RAP1A (interaction, mapped from reactome kegg_pathways)