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Baier et al., Cell Growth Differ 1999
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Our findings suggest that sustained MAPK activation via PI3Kgamma precedes ATRA -dependent differentiation or growth inhibition
Hehl et al., Biochem J 2001
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Expression of a constitutive active PI3Kgamma ( PI3Kgamma-CAAX ) induced GVBD and increased the levels of phosphorylated Akt/protein kinase B and mitogen activated protein kinase ( MAPK )
Bondeva et al., Science 1998
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Phosphoinositide 3-kinases (PI3Ks) activate protein kinase PKB ( also termed Akt ), and PI3Kgamma activated by heterotrimeric guanosine triphosphate binding protein can stimulate mitogen activated protein kinase ( MAPK ) ... Membrane targeted PI3Kgamma constitutively produced phosphatidylinositol 3,4, 3,4,5-trisphosphate and activated PKB but not MAPK ... Moreover, stimulation of MAPK in response to lysophosphatidic acid was blocked by catalytically inactive PI3Kgamma but not by hybrid PI3Kgammas