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MTOR — NF2

Text-mined interactions from Literome

Dasgupta et al., Cancer Res 2005 (Astrocytoma...) : Recent studies from our laboratory have shown that neurofibromin also regulates the mammalian target of rapamycin activity in a Ras dependent fashion, and that the rapamycin mediated mammalian target of rapamycin inhibition ameliorates the Nf1-/- astrocyte growth advantage
Hegedus et al., Cancer Res 2008 (Disease Models, Animal...) : Because neurofibromin negatively regulates mammalian target of rapamycin (mTOR) signaling , we showed that pharmacologic mTOR inhibition in vivo led to decreased tumor cell proliferation in a dose dependent fashion associated with a decrease in tumor volume ... Because neurofibromin negatively regulates mammalian target of rapamycin (mTOR) signaling, we showed that pharmacologic mTOR inhibition in vivo led to decreased tumor cell proliferation in a dose dependent fashion associated with a decrease in tumor volume
James et al., Mol Cell Biol 2009 (Meningioma...) : Merlin does not regulate mTORC1 via the established mechanism of phosphoinositide 3-kinase-Akt or mitogen activated protein kinase/extracellular signal regulated kinase mediated TSC2 inactivation and may instead regulate TSC/mTOR signaling in a novel fashion
López-Lago et al., Mol Cell Biol 2009 (Mesothelioma) : Loss of the tumor suppressor gene NF2 , encoding merlin, constitutively activates integrin dependent mTORC1 signaling