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MTOR — YY1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database mTOR signaling pathway:
mTORC1 complex (MTOR-MLST8-RPTOR)
→
YY1 (YY1)
(modification, collaborate)
Cunningham et al., Nature 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
mTORC1 complex (MTOR-MLST8-RPTOR)
→
mTORC1/PGC1A/YY1 complex (MTOR-MLST8-RPTOR-PPARGC1A-YY1)
(modification, collaborate)
Cunningham et al., Nature 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
YY1 (YY1)
→
mTORC1/PGC1A/YY1 complex (MTOR-MLST8-RPTOR-PPARGC1A-YY1)
(modification, collaborate)
Cunningham et al., Nature 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
PGC1A (PPARGC1A)
→
mTORC1/PGC1A/YY1 complex (MTOR-MLST8-RPTOR-PPARGC1A-YY1)
(modification, collaborate)
Cunningham et al., Nature 2007
Evidence: mutant phenotype, physical interaction
Text-mined interactions from Literome
Cunningham et al., Nature 2007
:
Moreover, mTOR and raptor interacted with YY1, and inhibition of
mTOR resulted in a failure of
YY1 to interact with and be coactivated by PGC-1alpha
Blättler et al., Mol Cell Biol 2012
:
Mechanistically,
mTOR dependent phosphorylation of
YY1 resulted in a strong interaction between YY1 and the transcriptional coactivator peroxisome proliferator activated receptor gamma coactivator 1a ( PGC1a ), a major regulator of mitochondrial function