◀ Back to MTOR
MTOR — RHEBP1
Text-mined interactions from Literome
Sato et al., J Biol Chem 2009
:
Both
Rheb1 and Rheb2
activate mTORC1
Zou et al., Dev Cell 2011
:
Rheb1 is
required for
mTORC1 and myelination in postnatal brain development ... Our study demonstrates that
Rheb1 is
essential for
mTORC1 signaling and myelination in the brain, and suggests that mTORC1 signaling plays a role in selective cellular adaptations, rather than general cellular viability
Bonneau et al., Mol Biol Rep 2012
:
The activation of
mTOR is
regulated by a small G-protein,
Rheb1
Wu et al., Am J Pathol 2013
(Cardiomegaly...) :
Cardiomyocyte apoptosis was reduced and mTORC1 activity was suppressed in cardiomyocyte Rheb1-deletion mice, suggesting that
Rheb1 regulates
mTORC1 activation in myocardium ... This study indicates that
Rheb1 is
essential for
mTORC1 activation in cardiomyocytes and suggests that targeting Rheb1-mTORC1 signaling, such as by As-IV treatment, may be an effective therapeutic method for treating patients with adverse cardiac remodeling after MI and hypertrophy