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MTOR — NA
Text-mined interactions from Literome
Chen et al., Lab Invest 2010
:
N-acetyl-L-cysteine (NAC) , a scavenger of reactive oxygen species ( ROS ),
blocked H ( 2 ) O ( 2 ) inhibition of
mTOR signaling
Lai et al., Arthritis Rheum 2012
(Lupus Erythematosus, Systemic) :
NAC increased d?m ( P = 0.0001 ) in all T cells, profoundly
reduced mTOR activity ( P = 0.0009 ), enhanced apoptosis ( P = 0.0004 ), reversed expansion of CD4-CD8- T cells ( mean ± SEM 1.35 ± 0.12-fold change ; P = 0.008 ), stimulated FoxP3 expression in CD4+CD25+ T cells ( P = 0.045 ), and reduced anti-DNA production ( P = 0.049 )