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ACD — NOTCH3

Text-mined interactions from Literome

Wang et al., Blood 2008 (Leukemia-Lymphoma, Adult T-Cell) : The results suggested that deregulated constitutive Rap1 activation caused abnormal expansion of DP thymocytes, bypassing the pre-T-cell receptor and eventually leading to Notch1 mutations and Notch dependent T-ALL
Tio et al., PloS one 2011 : We propose a model in which ACD results in differential Notch activation in direct siblings and in this context Notch acts as a repressor for DA neuronal specification in the sibling that receives active Notch signaling