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NOTCH3 — PTCRA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Reizis et al., Genes Dev 2002
:
We studied
Notch mediated
induction of the
pre-T cell receptor alpha (pTa) gene, a T-cell-specific transcriptional target of Notch ... The
pTa enhancer was
activated by
Notch signaling and contained binding sites for its nuclear effector, CSL
Talora et al., EMBO Rep 2003
(Lymphoma, T-Cell) :
We report here that
Notch3 induced transcriptional activation of
pTalpha/pre-TCR is responsible for the downregulation of E2A DNA binding and transcriptional activity
Bellavia et al., Cell cycle (Georgetown, Tex.) 2007
(Leukemia, T-Cell) :
We finally showed that the increased expression of non DNA binding Ikaros isoforms is able to restrain the inhibition exerted by Ikaros on
Notch3 dependent transcriptional activation of
pTa promoter, thus resulting in its significant upregulation
Campese et al., Int Immunol 2009
(Diabetes Mellitus, Type 1) :
Collectively, our data suggest that
pTalpha expression is required for the in vivo function of naturally occurring T ( reg ) s and that the activation of
Notch3 signaling may positively
regulate the function of this population, through the pTalpha/pre-T cell receptor pathway