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CASP3 — MAP3K1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAP3K1 → CASP3 (increases, CASP3 Activity, MAP3K1 Activity)
  Evidence: Caspase-dependent activation of kinases including PAK2, MEKK1, and PKCd also promotes cytoplasmic and nuclear apoptosis. Interestingly, MEKK1 activation enhances caspase activation, suggesting that kinases may amplify or initiate the caspase cascade.
• BioCarta hiv-1 nef: negative effector of fas and tnf: Caspase 3/6 inactivated kinases (PTK2/PRKCD/RIPK1/MAP3K1/PAK2) → Caspase 3 (active) (CASP3) (degradation, collaborate)
  
• KEGG MAPK signaling pathway: CASP3 → MAP3K1 (protein-protein, activation)
• NCI Pathway Database FAS (CD95) signaling pathway: Caspase 3 (tetramer) complex (CASP3) → MEKK1 (MAP3K1) (modification, activates) Deak et al., Proc Natl Acad Sci U S A 1998*
  Evidence: mutant phenotype, assay
• NCI Pathway Database Caspase Cascade in Apoptosis: Caspase 3 (CASP3) → MEKK1 (MAP3K1) (modification, activates) Widmann et al., Mol Cell Biol 1998*

Text-mined interactions from Literome

Gebauer et al., Int J Oncol 2000 (Adenocarcinoma...) : Analysis of the defective apoptotic pathway in 2008/C13 cells indicates that these cells are deficient in the proteolytic activation of MEKK1 by caspase-3
Villunger et al., J Immunol 2000 : It has been reported that cross linking Abs to Fas trigger c-Jun N-terminal kinase (JNK) signaling via caspase mediated activation of MEKK1 ( JNK kinase kinase ), elevation of ceramide levels or by recruitment of death domain associated protein ( DAXX ) to Fas
McGuire et al., J Biol Chem 2001 (Carcinoma, Squamous Cell) : Selective induction of caspase dependent MEK cleavage and up-regulation of MEKK-1
Schlesinger et al., J Biol Chem 2002 : Here, we show that caspase dependent cleavage of MEKK1 relocalizes the protease generated 91-kDa kinase fragment from a particulate fraction to a soluble cytoplasmic fraction
Bild et al., Oncogene 2002 : The mechanism for MEKK1 induced apoptosis involves caspase mediated cleavage of MEKK1 , releasing a pro-apoptotic 91 kDa kinase fragment that serves to further amplify caspase activation in a feedback loop ... MEKK1 induced apoptosis is amplified by blocking PI-3 kinase activation and overexpression of AKT blocked both MEKK1 induced apoptosis and caspase activation
Johnson et al., Cancer Metastasis Rev 2002 (Prostatic Neoplasms) : Calcitriol induces PARP cleavage, increases the bax/bcl-2 ratio, reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs, P-Erk-1/2 ) and phosphorylated Akt ( P-Akt ), induces caspase dependent MEK cleavage and up-regulation of MEKK-1 , all potential markers of the apoptotic pathway
Oida et al., Mol Cancer Ther 2007 (Lung Neoplasms) : Molecular analysis of Ad-mda7 treated H1299-dnI kappa B alpha tumors showed increased MEKK1 cleavage and activation of caspase-3 compared with Ad-mda7 treated H1299-Neo tumors
Widmann et al., Mol Cell Biol 1998 : Following activation by genotoxins, MEKK1 was cleaved in a caspase dependent manner into an active 91-kDa kinase fragment ... Expression of MEKK1 stimulated DEVD directed caspase activity and induced apoptosis
Deak et al., Proc Natl Acad Sci U S A 1998 : Activation of both SAPK and MEKK1 after Fas ligation is prevented by both viral and chemical caspase 3 inhibitors, which in contrast fail to block activation of SAPK by rapidly acting cell stresses