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FOSL2 — MAPK1

Text-mined interactions from Literome

Chen et al., J Biol Chem 2004 (MAP Kinase Signaling System) : PTHrP mediated down-regulation of PTH-1R mRNA and up-regulation of c-fos mRNA were MAPK independent, whereas PTHrP stimulation of fra-2 and interleukin-6 (IL-6) mRNA was MAPK dependent
Cook et al., Mol Cell Biol 1999 : In cells expressing a conditionally active form of Raf-1 ( DeltaRaf-1 : ER ), we observed that selective, sustained activation of Raf-MEK-MAPK was sufficient to induce expression of Fra-1, Fra-2 , and JunB but, interestingly, induced little or no c-Fos or c-Jun ... These results suggest that kinetically distinct phases of MAPK activation serve to regulate the expression of distinct AP-1 components such that sustained MAPK activation is required for the induced expression of Fra-1, Fra-2 , c-Jun, and JunB