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CD8A — MYD88

Text-mined interactions from Literome

Zhou et al., Eur J Immunol 2005 (Lymphocytic Choriomeningitis) : We investigated the roles of Toll-like receptor 2 (TLR2) and myeloid differentiation factor 88 ( MyD88 ) in the course of a lymphocytic choriomeningitis virus ( LCMV ) infection and revealed the following : ( i ) studies of transfected cells and murine peritoneal macrophages demonstrated that TLR2 and MyD88 are essential for the initial pro-inflammatory cytokine response ( human IL-8, mouse IL-6 ) to LCMV ; ( ii ) TLR2 knockout ( KO ) mice and MyD88 KO mice challenged with LCMV produced less IL-6 and monocyte chemotactic protein-1 in the serum than wild-type mice ; ( iii ) in contrast to inflammatory cytokines, the production of type 1 IFN ( IFN-alpha ) in response to LCMV was MyD88 independent ; ( iv ) MyD88 plays an essential role in antiviral CD8 ( + ) T cell responses, CD8 ( + ) T cells in MyD88 KO mice were defective in their expression of intracellular antiviral cytokines ; and ( v ) the failure of MyD88 KO mice to activate CD8 ( + ) T cells was accompanied by persistent viral infection in MyD88 KO mice
Zhao et al., J Immunol 2009 (Vaccinia) : Together, our results highlight an important role for MyD88 in initial antiviral CD8 T cell responses and suggest that targeting this pathway may be useful in promoting and sustaining anti-VACV immunity
Geng et al., Cancer Res 2010 (Melanoma...) : In this study, we examined the antitumor activity and survival of TLR2-MyD88 stimulated CD8 T cells derived from melanoma patients and T-cell receptor transgenic pmel mice
Sutherland et al., Immunol Cell Biol 2011 (Ectromelia, Infectious) : Using Toll-like receptor ( TLR ) and MyD88 gene knock-out ( GKO ) mice the effect of TLRs and MyD88 on virus replication, interferon ( IFN ) -ß production, natural killer ( NK ) cell and CD8T cell responses were assessed following ectromelia virus ( ECTV ) and recombinant vaccinia virus ( rVV ) infection
Rahman et al., Blood 2011 (Lymphocytic Choriomeningitis) : To address this, we used a novel, inducible knockout system to examine whether MyD88 is required for optimal memory CD8 T-cell generation and responses after lymphocytic choriomeningitis virus infection