Mojsilovic-Petrovic et al., Journal of neuroinflammation 2007
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HIF-1 binding sequence in the promoter of MCP-1 gene was cloned and transcriptional activation of MCP-1 by HIF-1alpha was analyzed by reporter gene assay ... These findings suggest that both MCP-1 and MCP-5 are HIF-1 target genes and that HIF-1alpha is involved in transcriptional induction of these two chemokines in astrocytes by hypoxia
Niu et al., J Biol Chem 2008
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Knockdown of MCPIP by small interfering RNA ( siRNA ) suppressed MCP-1 induced angiogenesis related gene VEGF and HIF-1alpha expression as well as tube formation