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IGF1R — IGFBP3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of IGF1-IGF1R → IGFBP3 (decreases) Kuemmerle et al., Am J Physiol Gastrointest Liver Physiol 2004*
  Evidence: IGFBP-3 inhibits the binding of IGF-I to its receptor and thereby inhibits IGF-I-stimulated growth.
• OpenBEL Selventa BEL large corpus: Complex of IGF1-IGF1R → IGFBP3 (decreases)
  Evidence: Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) is known to block IGF action and inhibit cell growth.
• OpenBEL Selventa BEL large corpus: IGF1R → IGFBP3 (decreases, IGFBP3 Activity)
  Evidence: exogenous IGFPB3 inhibits IGF1R activation and blocks phosphorylation of IRS1 in MCF-7 cells

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: IGF1R — IGFBP3 (association, biochemical) Mohseni-Zadeh et al., Endocrinology 1997*
• IRef Hprd Interaction: IGF1R — IGFBP3 (in vivo) Mohseni-Zadeh et al., Endocrinology 1997*
• IRef Ophid Interaction: IGF1R — IGFBP3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: IGF1R — IGFBP3 (aggregation, confirmational text mining) Mohseni-Zadeh et al., Endocrinology 1997*

Text-mined interactions from Literome

Brown et al., Domest Anim Endocrinol 2001 : Specific aims were to measure the levels of IGF binding protein-3 (IGFBP-3) and RNA encoding IGFBP-3 in the CL throughout diestrus, and to investigate the effects of IGFBP-2 and -3 on IGF-I stimulated progesterone ( P4 ) production and IGF-I-receptor binding
Wang et al., J Clin Invest 2008 (Carcinoma, Squamous Cell...) : In this issue of the JCI, Guix et al. demonstrate that downregulation of IGF binding protein 3 (IGFBP-3) and -4, the negative regulators of IGF-I receptor signaling, contributes to the resistance of human squamous cell carcinomas to the EGFR inhibitor gefitinib ( see the related article beginning on page 2609 )
Wu et al., Ocul Surf 2012 (Corneal Diseases...) : Taken together, these in vivo and confirmatory in vitro findings suggest that the observed increase in IGFBP3 found in human tears may attenuate IGF-1R signaling in the diabetic cornea