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MTOR — TFEB
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Peña-Llopis et al., EMBO J 2011
(MAP Kinase Signaling System) :
Regulation of
TFEB and V-ATPases by
mTORC1 ...
mTORC1 coordinately
regulates TFEB phosphorylation and nuclear localization and in a manner dependent on both TFEB and V-ATPases, mTORC1 promotes endocytosis
Settembre et al., EMBO J 2012
:
Conversely, pharmacological inhibition of
mTORC1 , as well as starvation and lysosomal disruption,
activates TFEB by promoting its nuclear translocation
Roczniak-Ferguson et al., Science signaling 2012
:
When lysosomal activity was adequate,
mTOR dependent phosphorylation of
TFEB on Ser ( 211 ) triggered the binding of 14-3-3 proteins to TFEB, resulting in retention of the transcription factor in the cytoplasm ... Inhibition of lysosomal function reduced the
mTOR dependent phosphorylation of
TFEB , resulting in diminished interactions between TFEB and 14-3-3 proteins and the translocation of TFEB into the nucleus, where it could stimulate genes involved in lysosomal biogenesis
Zhou et al., Cell Res 2013
:
Third, we examined the involvement of transcription factor EB (TFEB) and demonstrated that
TFEB activation following
mTORC1 suppression is necessary but not sufficient for lysosomal activation
Martina et al., J Cell Biol 2013
:
Interaction of TFEB with active Rag heterodimers promoted recruitment of TFEB to lysosomes, leading to
mTORC1 dependent phosphorylation and inhibition of
TFEB