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BECN1 — VPS41

Text-mined interactions from Literome

Malik et al., Oncogene 2011 : The BH3 mimetic ABT737 induces autophagy by competitively disrupting the inhibitory interaction between the BH3 domain of Beclin 1 and the anti-apoptotic proteins Bcl-2 and Bcl-X ( L ), thereby stimulating the Beclin 1-dependent allosteric activation of the pro-autophagic lipid kinase VPS34
Platta et al., Biochem J 2012 : Importantly, Nedd4 expression controls the stability of Beclin 1 , and depletion of the Beclin 1-interacting protein VPS34 causes Nedd4 mediated proteasomal degradation of Beclin 1 via Lys11 linked polyubiquitin chains
Abrahamsen et al., FEBS Lett 2012 (Neoplasms) : It is established that the overall activity of VPS34 is positively regulated by Beclin 1 , whose positive influence is further controlled through the association with a set of Beclin1 interacting components, which stimulate or inhibit VPS34