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CASP10 — CTNNB1

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Ling et al., Mol Pharmacol 2001 : All our data demonstrate that the caspase mediated cleavage of beta-catenin , gamma-catenin, and APC protein might contribute to paclitaxel induced apoptosis
Wong et al., Eur J Pharmacol 2001 : These data suggest that okadaic acid induced apoptosis is p38 MAPK and caspase dependent and that proteolytic cleavage of beta-catenin by caspases is likely to be a downstream molecular event associated with the morphological and cytoskeletal changes induced during apoptosis
Yusta et al., J Biol Chem 2002 : We now demonstrate that GLP-2, in a cycloheximide-insensitive manner, enhanced survival in baby hamster kidney cells stably transfected with the rat GLP-2R ; reduced mitochondrial cytochrome c efflux ; and attenuated the caspase dependent cleavage of Akt, poly ( ADP-ribose ) polymerase, and beta-catenin following inhibition of phosphatidylinositol 3-kinase (PI3K) by LY294002
Hwang et al., Leuk Res 2002 : Cleavage of intact beta-catenin was completely inhibited by caspase selective protease inhibitors
Li et al., Biochem Pharmacol 2002 (Adenomatous Polyposis Coli...) : Exisulind induced degradation of beta-catenin was not blocked by the inhibition of caspase-3 activity and/or apoptosis, and some SW480 cells showed a reduction in beta-catenin levels before the appearance of early apoptosis indicators
Jaiswal et al., Oncogene 2002 (Colonic Neoplasms) : Results described a caspase-3 mediated cleavage of beta-catenin , decreased transactivation of beta-catenin/Tcf-Lef, decreased promoter DNA binding activity of the beta-catenin/Tcf-Lef complex, and decreased levels of c-Myc protein
Wu et al., Exp Cell Res 2003 : In addition, general caspase inhibitors inhibited the cleavage of beta-catenin and poly ( ADP-ribose ) polymerase, and DNA fragmentation, whereas they did not prevent cell shape change or detachment
Cervello et al., Int J Mol Med 2004 (Carcinoma, Hepatocellular) : Induction of apoptosis by the proteasome inhibitor MG132 in human HCC cells : Possible correlation with specific caspase dependent cleavage of beta-catenin and inhibition of beta-catenin mediated transactivation ... The cleavage of beta-catenin was inhibited by the caspase inhibitors Z-VAD-fmk and Z-DEVD-fmk
Nakamoto et al., Int J Mol Med 2005 (Wilms Tumor) : Recently, caspase-3 dependent cleavage of beta-catenin was demonstrated to occur during apoptosis
Zhang et al., Neuroreport 2008 (Brain Ischemia...) : Inhibiting caspase-3 activity blocks beta-catenin degradation after focal ischemia in rat ... The caspase 3-specific inhibitor, Z-DQMD-FMK, attenuated beta-catenin degradation, but it did not affect phosphorylation of both beta-catenin and glycogen synthase kinase-3beta ... In conclusion, beta-catenin degraded after stroke, and its degradation was caspase-3 dependent
Marchong et al., PLoS Genet 2010 (Retinoblastoma) : Activated caspase-3 was significantly decreased and beta-catenin expression increased in Cdh11 knockdown experiments in vitro
Brancolini et al., J Cell Biol 1997 : Dismantling cell-cell contacts during apoptosis is coupled to a caspase dependent proteolytic cleavage of beta-catenin