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CASP10 — HSPD1

Text-mined interactions from Literome

Lin et al., Circulation 2001 (Myocardial Ischemia...) : We wanted to determine whether HSP60 and HSP10 could exert a protection against simulated ischemia and reoxygenation ( SI/RO ) -induced apoptotic cell death and whether such protection results from decreased mitochondrial cytochrome c release and caspase-3 activation and from the preservation of ATP levels by preservation of the electron transport chain complexes
Zhang et al., Exp Cell Res 2004 : Effects of UV radiation and exogenous hsp60 on phosphorylation of MAPKs and on activation of caspase 3 were examined by Western blot analysis
Chandra et al., J Biol Chem 2007 (Breast Neoplasms...) : Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release : evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3
Kim et al., Bone 2009 (Bone Resorption) : Consistent with these observations, HSP60 activated caspase-3 and -9, but not caspase-8 in HS-5 cells, and increased the release of mitochondrial cytochrome c into the cytosol ... Furthermore, Western blotting showed that HSP60 up-regulated TLR-2 and TLR-4 expression, and pretreatment with blocking antibodies for TLR-2 and TLR-4 almost completely eliminated the effects of HSP60 on apoptosis, caspase-3 and -9 activation, and activation of NFkappaB and p38 MAPK