◀ Back to HSP90AA1
HSP90AA1 — MAP3K7
Pathways - manually collected, often from reviews:
-
WikiPathways EBV LMP1 signaling:
Complex of MAP3K7-TAB1-MAP3K3-TRAF6
→
Complex of IKBKG-CHUK-IKBKB-HSP90AA1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
Complex of MAP3K7-CDC37-FKBP5-HSP90AA1-HSP90AB1-TAB1-TAB2
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Biogrid Interaction:
MAP3K7
—
HSP90AA1
(physical association, affinity chromatography technology)
Liu et al., FEBS Lett 2008
-
MIPS CORUM TNF-alpha/NF-kappa B signaling complex 7:
TNF-alpha/NF-kappa B signaling complex 7 complex (CDC37-FKBP5-HSP90AA1-HSP90AB1-MAP3K7-TAB1-TAB2-TAB3)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of HSP90AA1-MAP3K7-TAB1-CDC37-FKBP5-HSP90AB1-TAB3-TAB2
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Dip Interaction:
MAP3K7
—
HSP90AA1
(physical association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 57 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Intact Interaction:
Complex of CDC37-HSP90AA1-MAP3K7-TAB2-TAB1
(association, anti bait coimmunoprecipitation)
Liu et al., FEBS Lett 2008
-
IRef Intact Interaction:
Complex of TAB1-MAP3K7-HSP90AA1-CDC37
(association, anti bait coimmunoprecipitation)
Liu et al., FEBS Lett 2008
-
IRef Intact Interaction:
MAP3K7
—
HSP90AA1
(physical association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Intact Interaction:
Complex of CDC37-CDC37-HSP90AA1-MAP3K7-MAP3K7-HSP90AA1
(association, pull down)
Liu et al., FEBS Lett 2008
-
IRef Ophid Interaction:
MAP3K7
—
HSP90AA1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
MAP3K7
—
HSP90AA1
(aggregation, confirmational text mining)
Bouwmeester et al., Nat Cell Biol 2004
Text-mined interactions from Literome
Shi et al., Mol Immunol 2009
:
Silencing
Hsp90 expression through RNA interference ( RNAi ) also
down-regulated TAK1 , as well as attenuated IL-1beta induced phosphorylation of c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs, and degradation of IkappaBalpha
Liu et al., FEBS Lett 2008
(Inflammation) :
However,
Hsp90 is not
required for the activation of
TAK1 as short exposure to the Hsp90 inhibitor, 17- ( allylamino ) -17-demethoxygeldanamycin ( 17-AAG ) did not affect its activation by LPS or IL-1