Tirado et al., Oncogene 2005
:
Transient transfection studies using kinase-dead and rapamycin-resistant forms of mTOR demonstrated that only the downregulation of Bcl-xL was caused by the mTOR inhibitory action of rapamycin, which prevented cap dependent translation initiation, whereas Bax upregulation was induced by rapamycin through a mechanism independent of its mTOR inhibitory activity
Ramanathan et al., Proc Natl Acad Sci U S A 2009
:
Bcl-xl, but not VDAC1, is a kinase substrate for mTOR in vitro, and mTOR regulates the association of Bcl-xl with mTOR
Rahmani et al., Cancer Res 2013
(Leukemia, Myeloid) :
PI3K/mTOR inhibitors markedly downregulated Mcl-1 but increased Bim binding to Bcl-2/Bcl-xL ; the latter effect was abrogated by ABT-737