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FKBP8 — MTOR

Pathways - manually collected, often from reviews:

• WikiPathways Senescence and Autophagy in Cancer: FKBP8 → MTOR (inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Innatedb Interaction: FKBP8 — MTOR (unknown, -) Bai et al., Science 2007*

Text-mined interactions from Literome

Pieretti-Vanmarcke et al., Proc Natl Acad Sci U S A 2006 (Ovarian Neoplasms) : Because MIS releases FK506 binding protein ( FKBP12 ), which activates the mammalian target of rapamycin (mTOR) downstream of Akt, rhMIS and rapamycin combinations were tested
Wang et al., J Biol Chem 2008 : Furthermore, FKBP38 did not inhibit mTORC1 signaling ... Our data also indicate that, in the mammalian cell lines tested here, neither TCTP nor FKBP38 regulates mTORC1 signaling
Uhlenbrock et al., FEBS Lett 2009 : Cell biological experiments illustrate that FKBP38 plays only a very minor, if any, role in mTORC1 activation
Dunlop et al., Cell Signal 2009 : We found that FKBP38 inhibits mTOR ( L1460P ), while the mTOR ( E2419K ) kinase domain mutant was resistant to FKBP38 inhibition ... Finally, we show that activation of mTORC1 by both Rheb and RhebL1 is impaired by FKBP38
Peng et al., J Biol Chem 2010 : Overexpression of NS5A and FKBP38 mutants or FKBP38 knockdown revealed this mTOR activation was dependent on NS5A-FKBP38 interaction ... Additionally, NS5A or FKBP38 mutants recovered the mTOR-FKBP38 interaction ; this indicated that the impairment of mTOR-FKBP38 association was dependent on NS5A-FKBP38 binding
Yoon et al., J Biol Chem 2011 : This leads to PA antagonizing FKBP38 inhibition of mTORC1 kinase activity in vitro and rescuing mTORC1 signaling from FKBP38 in cells