Sandy et al., Biochem J 2001
(Knee Injuries) :
Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase ( ADAMTS ) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo
Otsuki et al., Proc Natl Acad Sci U S A 2010
(Osteoarthritis) :
MMP-13, ADAMTS-5 , and the BMP antagonist noggin were elevated whereas col2a1 and aggrecan were reduced in cartilage and chondrocytes from Sulf ( -/- ) mice
Boeuf et al., European cells & materials 2012
:
Despite this regulation of ADAMTS, no formation of NITEGE neoepitopes occurred in MSC pellets, indicating no ADAMTS induced cleavage of aggrecan