Gene interactions and pathways from curated databases and text-mining

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ACAN — CTGF

Text-mined interactions from Literome

Nishida et al., J Cell Physiol 2003 : Furthermore, CTGF/Hcs24 stimulated gene expression of the aggrecan gene, as well as DNA/proteoglycan synthesis, was diminished when HCS-2/8 cells were pretreated with heparinase, indicating that the effects of CTGF/Hcs24 on chondrocytes occurred through the interaction between CTGF/Hcs24 and heparan sulfate on the cells
Surmann-Schmitt et al., J Cell Physiol 2012 : In this study we demonstrate that Wif-1 is capable to interfere with CTGF dependent induction of Acan and Col2a1 gene expression in primary murine chondrocytes