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AHSA1 — RAC2
Text-mined interactions from Literome
Woo et al., Mol Cells 2002
(MAP Kinase Signaling System) :
Rac GTPase activity is
essential for lipopolysaccharide signaling to extracellular signal regulated kinase and
p38 MAP kinase activation in rat-2 fibroblasts
Dunford et al., J Bone Miner Res 2006
:
Paradoxically, although risedronate induces apoptosis of J774 macrophages by inhibiting protein prenylation, the p38 inhibitor SB203580 enhanced N-BP induced apoptosis, suggesting that
Rac induced
p38 activation partially suppresses the pro-apoptotic effect of N-BPs in these cells
Shifrin et al., Biochem J 2012
(Mechanotransduction, Cellular) :
Apoptosis was mediated by
Rac dependent activation of
p38a