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EPHB2 — PRKAG1

Text-mined interactions from Literome

Kim et al., J Biol Chem 2001 : Activation of AMPK by AICAR in NIH-3T3 cells resulted in drastic inhibitions of Ras, Raf-1, and Erk activation induced by insulin-like growth factor 1 (IGF-1)
Chen et al., J Biol Chem 2002 : In rat extensor digitorum longus (EDL) muscles, ( a ) AMPK activator, 5-aminoimidazole-4-carboxamide-1-beta-d-riboside ( AICAR ), activated PYK2, ERK and aPKCs ; ( b ) effects of AICAR on ERK and aPKCs were blocked by tyrosine kinase inhibitor, genistein, and MEK1 inhibitor, PD98059 ; and ( c ) effects of AICAR on aPKCs and 2-deoxyglucose ( 2-DOG ) uptake were inhibited by genistein, PD98059, and PLD-inhibitor, 1-butanol
Tosca et al., J Endocrinol 2006 : Adenovirus mediated expression of dominant negative AMPK totally restored the effects of AICAR on FSH induced progesterone secretion, StAR protein production, and ERK1/2 phosphorylation in F3/4 and F1 granulosa cells
Kodiha et al., Am J Physiol Cell Physiol 2007 : Taken together, our studies identify novel links between the physiological state of the cell, the activation of MEK-->ERK1/2 signaling, and the nucleocytoplasmic distribution of AMPK
Du et al., Biochem Biophys Res Commun 2008 : Conversely, activation of AMPK by AICAR also showed a significant inhibition of basal and serum induced ERK phosphorylation but it showed a delayed and steadfast inhibition which appeared after 60min and lasted until 12h
Soltoff et al., Am J Physiol Cell Physiol 2008 : Regulation of ERK1/2 by ouabain and Na-K-ATPase dependent energy utilization and AMPK activation in parotid acinar cells ... In native parotid cells, inhibitory effects of AMPK on ERK1/2 signaling were examined by activating AMPK with 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside ( AICAR ), which is converted to an AMP mimetic but does not alter parotid ATP levels
Babraj et al., Am J Physiol Endocrinol Metab 2009 (Diabetes Mellitus, Type 2) : At 3-h AMPK activity and AMPK, ACC and AS160 phosphorylation were unchanged, but ERK1/2 phosphorylation increased at both AICAR doses
Motobayashi et al., Hypertens Res 2009 : AMPK activation by AICAR inhibited IGF-1 induced ERK1/2 activation and cell migration in RASMCs
Wang et al., J Biol Chem 2009 : Activation of MEK/ERK by AMPK upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC
Sajan et al., Am J Physiol Endocrinol Metab 2010 (Second Messenger Systems) : Here, in cultured L6 myotubes : AICAR- and metformin induced activation of AMPK was required for activation of aPKC and ERK ; aPKC activation involved and required phosphoinositide dependent kinase 1 ( PDK1 ) phosphorylation of Thr410-PKC-zeta ; aPKC Thr410 phosphorylation and activation also required MEK1 dependent ERK ; and glucose transport effects of AICAR and metformin were inhibited by expression of dominant negative AMPK, kinase-inactive PDK1, MEK1 inhibitors, kinase-inactive PKC-zeta, and RNA interference ( RNAi ) -mediated knockdown of PKC-zeta
Kim et al., PloS one 2010 : Finally, the extracellular stresses caused by glucose deprivation or aminoimidazole carboxamide ribonucleotide ( AICAR ; AMPK activator ) regulate ( 14 ) C-glucose uptake and cell surface glucose transport (GLUT) 4 through ERK stimulation by AMPK mediated PLD1 activation
Welch et al., FEBS Lett 2010 (Hypercapnia) : Moreover, ERK inhibition prevented AMPK activation, a known modulator of hypercapnia induced Na, K-ATPase endocytosis
Pu et al., J Lipid Res 2011 : Weakening AMPK activity reduced phosphorylation of Akt but not ERK1/2 , and Akt inhibitor could not affect ERK1/2 activation either
Essick et al., Am J Physiol Heart Circ Physiol 2011 (Cardiomegaly...) : Thus APN inhibits ROS induced cardiomyocyte remodeling by activating AMPK and inhibiting ERK signaling and NF-?B activity
Kim et al., J Cell Physiol 2012 (MAP Kinase Signaling System) : In addition, inhibition or knockdown of AMPK during osteogenesis inhibited ERK phosphorylation, which is required for osteogenesis
Tillu et al., Molecular pain 2012 (Acute Pain...) : We reasoned that activators of AMP activated protein kinase (AMPK) may represent a novel treatment avenue for the local treatment of incision induced pain because AMPK activators inhibit ERK and mTOR signaling, two important pathways involved in the sensitization of peripheral nociceptors ... Our results demonstrate that resveratrol profoundly inhibits ERK and mTOR signaling in sensory neurons in a time- and concentration dependent fashion and that these effects are mediated by AMPK activation and independent of sirtuin activity
Martin et al., Cancer Discov 2012 : We further show that AMPK targets the dual-specificity protein phosphatase DUSP6 for degradation and this increases ERK activity, which then upregulates the VEGF-A protein
Paweł et al., Lipids 2013 (Leiomyoma...) : Additionally, in uterine leiomyomas we found relevant activation of both PTEN and MAPK(ERK1/2) signaling pathways with only a minor change in AKT activity and relatively absent HIF-1a/AMPK activation
Zhang et al., Mol Cell Endocrinol 2013 (Hyperuricemia...) : More importantly, activation of ERK induced by uric acid is significantly diminished by AMPK inhibitor, indicating ERK as a downstream target of AMPK in response to high uric acid condition