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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to PTEN

PTEN — TNFSF10

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: TNFSF10 → PTEN (increases)
    Evidence: In PTEN-deficient prostate carcinoma cell lines, FOXO1 and FOXO3 are cytoplasmically sequestered and inactive (Modur et al., 2002). In addition, the expression level of tumor necrosis factor family member TRAIL (tumor necrosis factor-related apoptosis-inducing ligand; Modur et al., 2002), a proapoptotic effector, is decreased (Modur et al., 2002).

Text-mined interactions from Literome

Wang et al., J Biol Chem 2002 : Similarly, overexpression of the tumor suppressor protein PTEN , an antagonist of PI 3-kinase signaling, resulted in the increased expression of TRAIL
Lee et al., Cell Res 2013 : Moreover, RFP mediated ubiquitination of PTEN inhibits PTEN dependent activation of TRAIL expression and also suppresses its ability to induce apoptosis