Ghosh-Choudhury et al., J Biol Chem 2006
:
Concerted action of Smad and CREB binding protein regulates bone morphogenetic protein-2 stimulated osteoblastic colony stimulating factor-1 expression ... However, the effect of BMP-2 on CSF-1 expression has not been studied ... We investigated the role of BMP-2 in CSF-1 expression in osteogenic C2C12 cells ... These data represent the first evidence that BMP-2 increases the osteoclastogenic CSF-1 expression by a transcriptional mechanism using the canonical Smad pathway and provide a mechanism for BMP-2 induced osteoclast differentiation
Fujita et al., Molecular cancer 2007
(Plasmacytoma) :
Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2 induced osteoblast differentiation and expression of OPG, RANKL and M-CSF Mandal et al., Endocrinology 2009
:
We have recently described the involvement of Smad 1/5 in BMP-2 induced CSF-1 expression and osteoclast formation ... Together, these data for the first time demonstrate that PI3K dependent Akt activation regulates BMP-2 induced CSF-1 expression and provides a mechanism for osteoblastic cell assisted osteoclast differentiation
Ghosh-Choudhury et al., J Biol Chem 2013
:
Interestingly, c-Abl regulated BMP-2 induced osteoclastogenic CSF-1 expression