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BMP2 — GREM1

Pathways - manually collected, often from reviews:

• NCI Pathway Database BMP receptor signaling: GREM1 (GREM1) → BMP2-4 (homodimer) complex (BMP4_BMP2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: GREM1 (GREM1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: GREM1 (GREM1) → BMP2-4/GREM1 complex (BMP4_BMP2-GREM1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/GREM1 complex (BMP4_BMP2-GREM1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/GREM1 complex (BMP4_BMP2-GREM1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMP2-4/GREM1 complex (BMP4_BMP2-GREM1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: RGM family (RGMB/RGMA/HFE2) → BMP2-4/GREM1 complex (BMP4_BMP2-GREM1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR2 (homodimer) complex (BMPR2) → BMP2-4/GREM1 complex (BMP4_BMP2-GREM1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BAMBI (BAMBI) → BMP2-4/GREM1 complex (BMP4_BMP2-GREM1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) → BMP2-4/GREM1 complex (BMP4_BMP2-GREM1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: BMP2 — GREM1 (in vitro) Keller et al., Nature structural & molecular biology 2004*

Text-mined interactions from Literome

Katoh et al., Int J Mol Med 2006 : GREM1 ( CKTSF1B1 ) inhibits BMP signaling through BMPR1A ( ALK3 ), BMPR1B ( ALK6 ) or ACVR1 ( ALK2 ) to SMAD1, SMAD5 or SMAD8
Suzuki et al., Calcif Tissue Int 2012 : BMP2 differentially regulates the expression of Gremlin1 and Gremlin2, the negative regulators of BMP function, during osteoblast differentiation ... We found that the expressions of Gremlin1 and Gremlin2, which are known BMP antagonists, were bidirectionally regulated by BMP2 ... Gremlin1 was down-regulated by BMP2 , while Gremlin2 was up-regulated in both time- and dose dependent manners ... The differential regulation of Gremlin1 and Gremlin2 gene expressions by BMP2 may explain the critical function of these genes during osteoblast differentiation
Tamminen et al., Oncogenesis 2013 : Here, we identify gremlin-1 , a known bone morphogenetic protein inhibitor crucial for embryonic development, as a potential therapeutic target for mesothelioma