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BMP2 — NODAL

Text-mined interactions from Literome

Yu et al., Dev Dyn 2008 : In this study, we demonstrate that BMP signaling is necessary and sufficient for the induction of Nodal expression in the chick LPM where the type I BMP receptor-IB ( BMPR-IB ) likely mediates this induction
Lenhart et al., Development 2011 : In contrast to previous reports, we find that Bmp represses Nodal signaling independently of lefty1 expression and through the activity of a ligand other than Bmp4
Pereira et al., Development 2012 : This suggests that BMP/Smad5 signaling contributes to negative regulation of Nodal
Katsu et al., Dev Biol 2013 : Multi-modal effects of BMP signaling on Nodal expression in the lateral plate mesoderm during left-right axis formation in the chick embryo ... Thus, the high and the low intermediate levels of BMP signaling up-regulated Nodal expression, but the high intermediate and low levels of BMP signaling down-regulated Nodal expression ... Next, we sought to identify the mechanisms of this complex regulation of Nodal expression by BMP signaling ... Nodal regulation by the high and low levels of BMP signaling was dependent on Cfc up-regulation or down-regulation, respectively ... We propose a model for the variable effects of BMP signaling on Nodal expression in which different levels of BMP signaling regulate Nodal expression by a balance between BMP-pSMAD1/4 signaling and NODAL-pSMAD2/4 signaling
Veerkamp et al., Dev Cell 2013 : We show that, in zebrafish, Nodal locally reduces Bmp activity on the left side of the cardiac field
Fleming et al., Development 2013 : We postulate that Nodal-like signaling regulates IM formation by modulating the IM-inducing effects of BMP signaling