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ABL1 — CASP3

Text-mined interactions from Literome

Yu et al., Cancer Res 2002 (MAP Kinase Signaling System) : Synergistic potentiation of STI571 mediated lethality by PD184352 was associated with multiple perturbations in signaling and apoptotic regulatory pathways, including caspase dependent down-regulation of Bcr-Abl and Bcl-2 ; caspase independent down-regulation of Bcl-x ( L ) and Mcl-1 ; activation of JNK, p38 MAPK, and p34 ( cdc2 ) ; and diminished phosphorylation of Stat5 and CREB
Di Bacco et al., Br J Haematol 2002 : During this process, caspase dependent cleavage of c-Abl and Bcr-Abl tyrosine kinases was observed, suggesting a new mechanism for the downregulation of the kinases during erythroid differentiation
Kim et al., Br J Haematol 2004 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Imatinib/apicidin co-treatment for 48 h produced a prominent decrease in Bcr-Abl protein levels in a caspase dependent manner ... In summary, these data indicate that apicidin potentiates the imatinib induced apoptosis of Bcr-Abl positive leukaemia cells through the enhanced activation of the mitochondria dependent caspase cascades, accompanied by caspase dependent downregulation of Bcr-Abl and XIAP
Deming et al., Mol Cell Biol 2004 : We report here that Bcr-Abl also inhibits caspase activation after the release of cytochrome c. Bcr-Abl inhibited caspase activation by cytochrome c added to cell-free lysates and prevented apoptosis when cytochrome c was microinjected into intact cells
Raina et al., J Biol Chem 2005 : Moreover, inhibition of c-Abl with STI571 blocked DNA damage induced autoprocessing of caspase-9 to the p35 subunit and activation of caspase-3
Holcomb et al., J Biol Chem 2006 : Furthermore, we demonstrate that attachment to an extracellular matrix plays a key role in regulating the apoptotic machinery through caspase mediated cleavage of Abl and Crk-Y221-P
Oxhorn et al., Proc West Pharmacol Soc 2005 : c-Abl is required for staurosporine induced caspase activity ... Here, we report c-Abl dependent caspase-3 and caspase-8 activity in response to staurosporine
Zhang et al., Leukemia 2008 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : We further showed that the ROS induced degradation of BCR-ABL was mediated partially by caspase-3 and the proteasome pathway
Liu et al., Breast Cancer Res 2010 (Breast Neoplasms) : ABL-N induced the activation of caspase-3 in estrogen receptor ( ER ) -negative cell lines MDA-MB-231 and MDA-MB-468, as evidenced by the cleavage of endogenous substrate Poly ( ADP-ribose ) polymerase ( PARP )
Kurokawa et al., Proc Natl Acad Sci U S A 2013 (Leukemia) : Engineering a BCR-ABL activated caspase for the selective elimination of leukemic cells