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CASP3 — IL4

Text-mined interactions from Literome

Lee et al., FEBS Lett 2000 : In addition, IL-4 markedly increased activity of caspase-3 , and inhibition of this enzyme suppressed IL-4 induced apoptosis in a dose dependent manner
Burgess et al., J Neuroimmunol 2003 : IL-4 inhibits caspase-3 activity and promotes promyeloid cell survival by a substrate for PI 3-kinase that is not Akt
Doseff et al., Am J Respir Cell Mol Biol 2003 : IL-4 did not affect the activity of caspase-3 or the fragmentation of DNA in nonstimulated monocytes, suggesting that the induction of the apoptotic cascade by IL-4 is specific for stimulated monocytes
Arreaza et al., Clin Immunol 2003 (Diabetes Mellitus, Type 1) : IL-4 reduces this c-FLIP expression and increases caspase-3 and -8 activity in activated NOD CD8+ T cells
Guo et al., Blood 2003 : In the present study we confirm that Fas signaling induces both phenotypic and functional maturation of murine DCs, and we demonstrate that phenotypic maturation is associated with phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2, activation of caspase-1 , and secretion of interleukin-beta ( IL-1beta )
Wang et al., Ann Thorac Surg 2005 (Reperfusion Injury) : Myocardial tissue was then assessed for products of p38 MAPK activation, expression of tumor necrosis factor, interleukin-1beta and interleukin-6, and activation of caspase-1, caspase-3 and caspase-11
Rautajoki et al., Mol Cell Proteomics 2007 : Interleukin-4 inhibits caspase-3 by regulating several proteins in the Fas pathway during initial stages of human T helper 2 cell differentiation ... Taken together, our results indicate that IL-4 inhibits caspase activity during the initial stages of human Th2 cell differentiation by regulating expression of several key players in the Fas induced pathway
Aoudjehane et al., FASEB J 2007 : IL-4 reduced the mitochondrial membrane potential, activated Bid and Bax, and augmented caspase 3, 8, and 9 activity
Lin et al., Allergy 2007 (Dermatitis, Atopic) : The aims of this study were to ( 1 ) determine whether there are differences between AD patients and healthy subjects in SsAg induced caspase-3 activation and SsAg induced changes of anti-apoptotic protein Bcl-2 and Bcl-2 mRNA levels of CD4+ T cells ; ( 2 ) investigate the effect of interleukin (IL)-4 on SsAg induced caspase-3 activation and SsAg induced changes of Bcl-2 and Bcl-2 mRNA levels of CD4+ T cells ... Exogenously added IL-4 inhibited SEB induced caspase-3 activation and SEB induced decrease of Bcl-2 and Bcl-2 mRNA in SEB-reactive CD4+ T cells from healthy subjects ... Inhibition of endogenous IL-4 by using anti-IL-4 neutralizing antibodies up-regulated SEB induced caspase-3 activation and SEB induced decrease of Bcl-2 and Bcl-2 mRNA in SEB-reactive CD4+ T cells from AD patients
Shushanov et al., Bull Exp Biol Med 2010 : Insulin-like growth factor-1 and insulin inhibit caspase-3/7 activation initiated by interleukin-1ß in the rat eye retinal neurons
Soria et al., Neurobiol Dis 2011 : Mechanistic studies revealed that, in microglial cells, IL-4 increased the levels of cleaved caspase 3 and PARP, which is down-stream of activated caspase 3
Liao et al., Inflamm Res 2013 : Lipopolysaccharide/adenosine triphosphate mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1 mediated interleukin-1ß secretion