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CSF2 — LTB

Text-mined interactions from Literome

DiPersio et al., J Immunol 1988 : GM-CSF enhances neutrophil arachidonic acid release and LTB4 synthesis, and thereby may amplify the inflammatory response to chemotactic factors and other physiologically relevant stimuli
Poubelle et al., Agents Actions 1989 : Granulocyte-macrophage colony stimulating factor ( GM-CSF ) and opsonization synergistically enhance leukotriene B4 (LTB4) synthesis induced by phagocytosis in human neutrophils ... The most striking effect of phagocytosis was observed when neutrophils were primed with granulocyte-macrophage colony stimulating factor ( GM-CSF ) : opsonization and GM-CSF synergistically increased LTB4 synthesis by neutrophils
Stanková et al., Blood 1995 : Collectively, our data imply that GM-CSF can regulate LTB4 production by two distinct mechanisms : a short-term increase that is not related to increased 5-LOX mRNA expression and is independent of protein synthesis, and a sustained increase in LTB4 production that is associated with the transcriptional activation of the 5-LOX gene, increase in 5-LOX mRNA levels, and dependence on protein synthesis