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Huan et al., Toxicol Appl Pharmacol 2004
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In contrast, NADPH cytochrome P450 reductase which is constitutively expressed in Tc-HeLa cells had a half-life of about 30 h. Lactacystin and other selective proteasome inhibitors including N-benzyloxycarbonyl-leucyl-leucyl-leucinal ( MG132 ) and N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-norvalinal ( MG115 ) significantly inhibited both CYP2E1 and CYP2B1 degradation
Lengler et al., Biochem Pharmacol 2006
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We have analysed a set of cell lines for the effects of CPR on cytochrome P450 isoform 2B1 (CYP2B1) activity ... Thus, our data reveal an effect of CPR on CYP2B1 activity dependent on the cell type used and therefore demand a careful evaluation of the therapeutic benefit of combining cytochrome P450 and CPR in respective in vivo models in each individual target tissue to be treated
van Bezooijen et al., Exp Gerontol 1994
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Expression of hepatic NADPH cytochrome P450 reductase , phenobarbital induced CYP2B1 & 2, and the polymeric immunoglobulin receptor (pIgR) decline as a function of aging