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EPHB2 — IL10

Text-mined interactions from Literome

Sato et al., J Immunol 1999 : TNF-alpha induced tyrosine phosphorylation and enzymatic activation of ERK2 , SAPK/JNK, and p38mapk, whereas IL-10 did not induce these events
Valledor et al., J Biol Chem 2000 : Granulocyte/macrophage colony stimulating factor, interleukin 3, and TPA, all of which induced macrophage proliferation, also induced ERK activity, which was maximal at 5 min poststimulation
Zhou et al., J Immunol 2001 : Wortmannin and LY294002 also totally inhibited activation of extracellular signal related kinase ( ERK ) 1/2 by IL-10 ... Direct inhibition of ERK1/2 with the mitogen activated protein kinase/ERK kinase inhibitor PD98059 partially, but significantly, impaired the anti-apoptotic activity of IL-10
Nagano et al., Int Immunol 2002 : Taken together, these results suggest that both ERK and p38 ( MAPK ) pathways are involved in LPS induced COX-2 expression and PGE ( 2 ) production in neutrophils, and IL-10 and IL-4 inhibit neutrophil prostanoid synthesis by down regulating the activation of p38 ( MAPK )
Hall et al., J Cell Biochem 2002 (MAP Kinase Signaling System) : IL-6 induced M1 differentiation also induces expression of the anti-inflammatory cytokine IL-10, and p38 inhibition potentiates this increase in IL-10 expression in an ERK dependent manner ... Thus, we speculate that during inflammatory conditions in vivo macrophage p38 may regulate JNK and ERK activity and inhibit IL-10 expression
Feito et al., Eur J Immunol 2003 (MAP Kinase Signaling System) : ERK or JNKinhibitors partially inhibited IL-4 and IL-10 secretion, while PKC or p38 inhibitors had no significant effects on IL-4 or IL-10 secretion
Maggi et al., J Biol Chem 2003 (Cardiovirus Infections...) : ERK activation is required for double stranded RNA- and virus induced interleukin-1 expression by macrophages
MacGillivray et al., J Biol Chem 2003 (MAP Kinase Signaling System) : The protein tyrosine phosphatase SHP-2 regulates interleukin-1 induced ERK activation in fibroblasts
Xia et al., Scand J Immunol 2003 : In addition, inhibition of ERK by PD98059 significantly suppressed IL-10 and increased the IL-12 production ... The above findings suggest a unidirectional negative autocrine regulation of IL-12 by IL-10 in activated DCs and that activation of ERK involves the differential production of IL-10 and IL-12 by activated DCs
Makuta et al., Biol Pharm Bull 2003 : In addition, IL-10 induced tyrosine (Tyr) phosphorylation of Erk , as well as serine ( Ser ) and Tyr phosphorylation of STAT-3
Xie et al., J Immunol 2003 : Furthermore, LPS up-regulated the secretion of IL-1beta, IL-6, IL-8, IL-10 , and TNF-alpha ; reduced Ag presentation capacity ; and inhibited phosphorylation of ERK , but activated p38, leading to a reduced NF-kappaB activity in treated cells
Inoue et al., J Immunol 2004 (MAP Kinase Signaling System) : IL-10 significantly inhibited CD40 induced activation of the ERK , p38 MAPK, and NF-kappaB pathways ; however, inhibition by IL-4 was limited to the ERK pathway in monocytes
Chang et al., J Biol Chem 2004 (Inflammation...) : The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation
Wang et al., J Biol Chem 2005 : SHP-2 modulates interleukin-1 induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1
Correa et al., Br J Pharmacol 2005 : 5 Inhibition of ERK by PD98059 significantly suppressed IL-10 production by LPS activated macrophages
Rahimi et al., J Immunol 2005 : IL-10 induced the phosphorylation of PI3K and p42/44 ERK MAPK
Lucas et al., J Immunol 2005 : The inhibition of either ERK or p38 prevented IL-10 induction, indicating that both MAPKs were required for IL-10 synthesis
Jung et al., J Clin Immunol 2005 (MAP Kinase Signaling System...) : The analysis of cytokine production using specific inhibitors of the MAPK pathway revealed that both p38 and ERK activation are essential for PPD induced TNF-alpha production, whereas p38, but not ERK , activation is essential for IL-10 secretion
Miranda et al., Leuk Res 2005 (MAP Kinase Signaling System) : Additionally, interleukin-3 , which inhibits G-CSF induced differentiation of 32 Dc l3 cells, also inhibited the ability of G-CSF to stimulate prolonged MEK/ERK activation
Loscher et al., J Immunol 2005 : Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK mediated IL-10 induction
Dang et al., FASEB J 2006 : We found that IL-10 inhibited GM-CSF induced ERK1/2 activity in an immunocomplex kinase assay
Qian et al., Blood 2006 : TLR agonists promote ERK mediated preferential IL-10 production of regulatory dendritic cells ( diffDCs ), leading to NK-cell activation
Saegusa et al., Mol Immunol 2007 : A specific ERK inhibitor, U0126, as well as PI3K inhibitors, differentially regulated IL-10 and IL-12 p70 productions ... These results suggest that PI3K positively and negatively regulates the production of CpG-ODN induced IL-10 and IL-12 p70, respectively, and negatively regulates IL-12 p70 production in macrophages through ERK mediated IL-10 induction
Prêle et al., Immunology 2006 : SOCS3 over-expression had no effect on TNF-alpha mRNA levels induced by LPS or LPS plus IL-10 , or on IL-10 phosphorylation of STAT3, STAT1 and ERK1/2
Slack et al., Eur J Immunol 2007 : Syk dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan
Strle et al., J Neuroimmunol 2007 : This protection occurs without decreasing global activity of TNF receptors since IL-10 does not impair TNFalpha induced IL-6 synthesis or ERK1/2 phosphorylation
Yotsumoto et al., J Immunol 2008 : We show in this study that peritoneal macrophages from SCID mice having mutations in the catalytic subunit of DNA-protein kinase ( DNA-PKcs ) were almost completely defective in the production of IL-10 and in ERK activation when treated with CpG-ODN
Park et al., J Leukoc Biol 2008 : Inhibition of either ERK1/2 or PKA activity prevented gAcrp stimulated CREB phosphorylation, as well as gAcrp stimulated IL-10 promoter activation
Strle et al., Am J Physiol Endocrinol Metab 2008 (MAP Kinase Signaling System) : IL-10 blocks IL-1beta induced phosphorylation of JNK, but not ERK1/2 or p38, indicating that only the JNK component of the IL-1beta induced MAPK signaling pathway is targeted by IL-10
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Resveratrol inhibits high glucose induced PI3K/Akt/ERK dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Hoarau et al., PloS one 2008 (Hypersensitivity...) : We found that 1 ) the PI3K pathway was positively involved in the prolonged DC survival induced by BbC50sn, LPS and Zymosan in contrast to p38MAPK and GSK3 which negatively regulated DC survival ; 2 ) p38MAPK and PI3K were positively involved in DC maturation, in contrast to ERK and GSK3 which negatively regulated DC maturation ; 3 ) ERK and PI3K were positively involved in DC-IL-10 production, in contrast to GSK3 that was positively involved in DC-IL-12 production whereas p38MAPK was positively involved in both ; 4 ) BbC50sn induced a PI3K/Akt phosphorylation similar to Zymosan and a p38MAPK phosphorylation similar to LPS
Woolson et al., Cell Signal 2009 : Here we demonstrate that elevation of cyclic AMP ( cAMP ) levels in human umbilical vein endothelial cells ( HUVECs ) specifically attenuates ERK1,2 activation in response to either leptin or a soluble interleukin IL-6 receptor-alpha/IL-6 ( sIL-6R alpha/IL-6 ) trans signalling complex but not protein kinase C activator phorbol 12-myristate 13-acetate
Saraiva et al., Immunity 2009 : Interleukin-10 production by Th1 cells requires interleukin-12 induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose ... Interleukin-10 production by Th1 cells requires interleukin-12 induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
Cuong et al., Life Sci 2009 (Inflammation...) : Pre-treatment with C-K significantly inhibited zymosan mediated secretion of tumor necrosis factor-alpha, interleukin (IL)-6 , and IL-12 p40, and the activation of ERK1/2 and p38
Kaji et al., J Immunol 2010 : The effect of these teichoic acids on IL-10 production was mediated by TLR2 dependent ERK activation
Xuan et al., Cell Physiol Biochem 2010 : Both LPS and GA stimulated the production of IL-6, IL-10 , IL12p70 and TNFalpha in a p38- and/or ERK dependent manner
Patel et al., J Cell Mol Med 2012 (Carcinoma, Non-Small-Cell Lung...) : IL-10 production in non-small cell lung carcinoma patients is regulated by ERK , P38 and COX-2
Guindi et al., Cell Immunol 2012 (MAP Kinase Signaling System) : ERK1/2 and AP-1 were involved in IL-10 production in GM/DCs but not in their resistance to maturation
Noh et al., J Biol Chem 2012 (Endotoxemia) : Taken together, IL-10 expression produced by GSK-3 inhibition induced ERK1/2 activation via PKCd relieved LPS mediated endotoxemia
Wi et al., Cytokine 2012 (MAP Kinase Signaling System) : Additionally, CA treatment induced ERK and JNK phosphorylation, and unexpectedly, elevated levels of IL-10 and TGF-ß were inhibited by the addition of an ERK-specific inhibitor
Ng et al., PloS one 2013 : Further, ERK overexpression increased IL-10 promoter activity stimulated by wild-type human GR but not by its mutant defective in serine 203, whereas ERK knockdown abolished NDV/DEX cooperation on IL-10 mRNA and phosphorylation of the mouse GR at serine 213
Lo et al., J Biol Chem 1998 : Requirements of focal adhesions and calcium fluxes for interleukin-1 induced ERK kinase activation and c-fos expression in fibroblasts
Egerton et al., Int Immunol 1998 : However, the production of IL-3 and IL-4 was only partially dependent upon ERK activation, whereas IL-5, IL-10 , IFN-gamma and GM-CSF production was severely affected by diminished ERK activation
Niiro et al., Biochem Biophys Res Commun 1998 : Interestingly, LPS induced phosphorylation and activation of ERK2 was significantly inhibited by IL-4 and IL-10 , while that of p38 MAPK was inhibited by IL-10, but not IL-4