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IL10 — PDE4B

Text-mined interactions from Literome

Wang et al., Mol Pharmacol 1999 : Very recently, we found in monocytes that PDE4B gene expression is selectively induced by lipopolysaccharide (LPS) and that the induction is inhibited by interleukin (IL)-10 and IL-4
Ma et al., Mol Pharmacol 1999 : We also demonstrate that LPS induction of PDE4B mRNA expression was inhibited strongly by interleukin (IL)-10 ... Interestingly, unlike LPS induction, the dibutyryl-cAMP induction of PDE4B mRNA expression was not inhibited by IL-10 ... By performing nuclear run-on and mRNA stability assays, we demonstrate further that IL-10 inhibited LPS stimulated PDE4B mRNA synthesis by abolishing the gene transcription rather than by enhancing mRNA degradation