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IL10 — SERPINF1

Text-mined interactions from Literome

Yang et al., Life Sci 2010 : In search for the anti-inflammation mechanism of PEDF, we investigate whether pigment epithelium derived factor (PEDF) induces the gene expression of interleukin (IL)-10 in human macrophages and determine the molecular basis of this induction ... Pharmacological inhibitors were used to examine the involvement of ERK, p38 MAPK, and peroxisome proliferator activated receptor gamma ( PPARgamma ) on the IL-10 expression induced by PEDF ... Blockade of activity of ERK or p38 MAPK attenuated PEDF effects on induction of PPARgamma and IL-10 ... PEDF increased the transcriptional activity of IL-10 promoter ... These results showed that PEDF promotes IL-10 expression at transcriptional level, and that this is achieved through the ERK2/p38MAPK dependent PPARgamma expression
Nelius et al., Prostate 2013 (Prostatic Neoplasms...) : Finally, PEDF stimulated the expression of iNOS, IL12, and TNFa ; and inhibited IL10 and arginase 1 in mouse and human macrophages confirming a M1-type differentiation