Yang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2003
:
[ Study on a new IL-12 inducing gene NAP2 ] ... NAP2 could activate NF-kappaB and IL-12 promoter ... In addition, NAP2 could induce IL-12 expression in macrophage cell line J774 ... NAP2 as a newly cloned NF-kappaB activating gene can activate IL-12 promoter and induce IL-12 expression in macrophages
Del Prete et al., J Allergy Clin Immunol 2008
(Disease Models, Animal...) :
This study provides evidence that HP-NAP enhances endogenous IL-12 and IFN-gamma response and exerts a powerful anti-T ( H ) 2 activity in vivo, targeting both IL-5 induced eosinophilia and IL-4 mediated hyper-IgE responses induced by parasitic infection
Chiumiento et al., Int J Immunopathol Pharmacol 2011
(Disease Models, Animal...) :
The neutrophil Activating protein of Helicobacter pylori ( HP-NAP ), that induces IL-12 , and IL-23 expression and shifts to Th1 allergen-specific Th2 cells in vitro was used as an anti-Th2 agent in BALB/c mice infected with T. spiralis